The eyes of the sporting world will be on the Etihad Stadium this weekend as Manchester City and Manchester United battle for local supremacy.
The two clubs are underperforming this term and desperately need to improve as the 2024/25 season heads towards the busy festive period.
Read on as we look at some of the top Premier League games for Matchday 16 to highlight the key angles to consider on football betting sites.
Premier League Matchday 16 Preview: Manchester Duo Take Centre Stage

Premier League Matchday 16 Preview: Manchester Duo Take Centre Stage
Highlights
- Manchester derby is a tricky betting proposition.
- Short-priced four-fold looks tempting.
- Over 2.5 goals multiple worth chancing again.
City & United Desperately Need a Boost
Man City and Man United have both been inconsistent this season and must step things up if they are to salvage something from their respective campaigns.
Home advantage should give City the edge, but it would be a risky move to wager on them given their poor run of results in recent weeks.
Backing over 2.5 goals and over 4.5 corners for both teams in the match at odds of 7/2 on UK betting apps could be the sensible way to play this one.
Four-Fold is Worth a Punt
Title-chasers Liverpool, Chelsea and Arsenal all have winnable looking home games this weekend and can form the core of a tempting multiple.
Newcastle United are also fancied to beat Leicester City at St James’ Park to complete a near 2/1 four-fold on numerous betting sites in the UK.
Adding Tottenham Hotspur to win at Southampton boosts the odds to almost 5/1, although it generally pays not to be overly ambitious with multiple bets.
Over 2.5 Goals Can Deliver Again
We have successful tipped over 2.5 goals trebles in three of the last four Premier League Matchdays, with just one result letting us down for a clean sweep.
The games at Arsenal, Nottingham Forest and Chelsea look primed to hit that mark and deliver another winning return to punters who keep the faith.
Odds of almost 7/2 on several new betting sites should provide a tasty payout for bettors ahead of the Christmas and New Year period.
Premier League Matchday 16 Odds (via QuinnBet)
Fixtures | Home | Draw | Away |
Liverpool vs Fulham | 1/3 | 9/2 | 15/2 |
Arsenal vs Everton | 2/9 | 5/1 | 12/1 |
Wolverhampton Wanderers vs Ipswich Town | 19/20 | 14/5 | 11/4 |
Newcastle United vs Leicester City | 3/10 | 5/1 | 8/1 |
Nottingham Forest vs Aston Villa | 13/8 | 23/10 | 17/10 |
Brighton & Hove Albion vs Crystal Palace | 10/11 | 11/4 | 14/5 |
Manchester City vs Manchester United | 4/7 | 18/5 | 4/1 |
Chelsea vs Brentford | 1/3 | 5/1 | 7/1 |
Southampton vs Tottenham Hotspur | 16/5 | 10/3 | 8/11 |

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